4-(2-Cyclohexyl-acetylamino)-phenyl chloroformate → 4-Pyridin-3-ylmethyl-piperazine-1-carboxylic Acid 4-(2-cyclohexyl-acetylamino)-phenyl Ester

HRID 1179974Notes

Reaction equation

HRID 1179974 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)=[O:3].Cl.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:23]=1>>[CH:14]1([CH2:13][C:12]([NH:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:32]3[CH2:33][CH2:34][N:29]([CH2:28][C:24]4[CH:23]=[N:22][CH:27]=[CH:26][CH:25]=4)[CH2:30][CH2:31]3)=[O:3])=[CH:6][CH:7]=2)=[O:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 220478864-(2-Cyclohexyl-acetylamino)-phenyl chloroformateHCID 45074811Piperazine, 1-(3-pyridinylmethyl)-, hydrochloride (1:1)

Product 1

HCID 574736804-Pyridin-3-ylmethyl-piperazine-1-carboxylic Acid 4-(2-cyclohexyl-acetylamino)-phenyl Ester

Procedure

The title compound was prepared from 4-(2-cyclohexyl-acetylamino)-phenyl chloroformate and 1-pyridin-3-ylmethyl-piperazine, hydrochloride, preparative HPLC (method C) (64%, white crystals). HPLC-MS m/z=437.4 (M+1), Rt: 2.38 min.

Sources & evidence

ORD record
ord-59fb23b5947c499e819ed5c8a4d2b764
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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