4-Piperidinemethanol → 4-Hydroxymethyl-piperidine-1-carboxylic Acid 4-(2-cyclohexyl-acetylamino)-phenyl Ester

HRID 1179979Notes

Reaction equation

HRID 1179979 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:7][CH:6]=1)=[O:3].[OH:21][CH2:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH:14]1([CH2:13][C:12]([NH:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:26]3[CH2:27][CH2:28][CH:23]([CH2:22][OH:21])[CH2:24][CH2:25]3)=[O:3])=[CH:6][CH:7]=2)=[O:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 4207714-PiperidinemethanolHCID 220478864-(2-Cyclohexyl-acetylamino)-phenyl chloroformate

Product 1

HCID 695185664-Hydroxymethyl-piperidine-1-carboxylic Acid 4-(2-cyclohexyl-acetylamino)-phenyl Ester

Procedure

The title compound was prepared from 4-(2-cyclohexyl-acetylamino)-phenyl chloroformate and 4-hydroxymethyl-piperidine, preparative HPLC (Method C) (37%, off-white crystals). HPLC-MS m/z=375.2 (M+1), Rt: 3.41 min.

Sources & evidence

ORD record
ord-9b01e2323bb7451ea67b11b7c7832e66
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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