4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate → 4-(4-Amino-phenyl)-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

HRID 1179980Notes

Reaction equation

HRID 1179980 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].Cl.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[CH:26][CH:25]=1>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:33]3[CH2:34][CH2:35][CH:30]([C:27]4[CH:26]=[CH:25][C:24]([NH2:23])=[CH:29][CH:28]=4)[CH2:31][CH2:32]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 467352184-(Piperidin-4-YL)aniline hydrochloride

Product 1

HCID 695196604-(4-Amino-phenyl)-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 4-(4-aminophenyl)piperidine, hydrochloride, preparative HPLC (Method C) (30%, light yellow crystals). HPLC-MS m/z=458.2 (M+1), Rt: 3.42 min.

Sources & evidence

ORD record
ord-82a10c0c211f4527b0a56bb238b2ce9a
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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