HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate → 4-(4-Amino-phenyl)-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| Reactant | 4-(Piperidin-4-YL)aniline hydrochloride | HCID 46735218 | — |
| Product | 4-(4-Amino-phenyl)-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester | HCID 69519660 | — |
Reaction Steps
The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 4-(4-aminophenyl)piperidine, hydrochloride, preparative HPLC (Method C) (30%, light yellow crystals). HPLC-MS m/z=458.2 (M+1), Rt: 3.42 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279470B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-82a10c0c211f4527b0a56bb238b2ce9a |
| Source note | uspto-grants-2007_10 |