N-Methyl-4-anisidine → 4-[[5-(Trifluoromethyl)-2-pyridinyl]oxy]phenyl N-(4-methoxyphenyl)-N-methylcarbamate

HRID 1179994Notes

Reaction equation

HRID 1179994 reaction equation
[CH3:1][NH:2][C:3]1[CH:10]=[CH:9][C:6]([O:7][CH3:8])=[CH:5][CH:4]=1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][N:23]=2)=[CH:17][CH:16]=1)=[O:13]>>[F:29][C:28]([F:31])([F:30])[C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[CH:19]=[CH:20][C:15]([O:14][C:12](=[O:13])[N:2]([C:3]3[CH:10]=[CH:9][C:6]([O:7][CH3:8])=[CH:5][CH:4]=3)[CH3:1])=[CH:16][CH:17]=2)=[N:23][CH:24]=1

Participants

3

Reactant 2

HCID 22250N-Methyl-4-anisidineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 236356334-[[5-(Trifluoromethyl)-2-pyridinyl]oxy]phenyl N-(4-methoxyphenyl)-N-methylcarbamate

Procedure

The title product was prepared from N-methyl-p-anisidine and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, preparative HPLC (method C) (61%, off-white crystals). HPLC-MS m/z=419.2 (M+1), Rt: 4.67 min.

Sources & evidence

ORD record
ord-60df9c33a4c54ed096c21991a6c9da7c
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

Loading…