3,3-Dimethylglutaric anhydride → HCID 22047706, compound

HRID 1180013Notes

Reaction equation

HRID 1180013 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:6][CH:7]=1.[CH3:19][C:20]1([CH3:28])[CH2:26][C:25](=[O:27])[O:24][C:22](=[O:23])[CH2:21]1>ClCCl>[CH3:19][C:20]([CH3:28])([CH2:26][C:25](=[O:27])[NH:1][C:2]1[CH:7]=[N:6][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1)[CH2:21][C:22]([OH:24])=[O:23]

Participants

4

Reactant 2

HCID 778133,3-Dimethylglutaric anhydrideHCID 69465626HCID 69465626, compound

Product 1

HCID 22047706HCID 22047706, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of methyl-phenyl-carbamic acid 5-amino-pyridin-2-yl ester (243 mg, 1.00 mmol) and 3,3-dimethylglutaric anhydride (142 mg, 1.00 mmol) in dichloromethane (10 mL) was stirred at room temperature for 48 hours. Evaporation of the solvent yielded the title compound as a thick oil.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-8700b09099214e8eb2d34b59112d4302
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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