Diisopropylamine → HCID 69517606, compound

HRID 1180021Notes

Reaction equation

HRID 1180021 reaction equation
[CH:1]1([N:4]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[CH:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:3][CH2:2]1.Cl[C:20]([O:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][N:31]=2)=[CH:25][CH:24]=1)=[O:21].C(NC(C)C)(C)C>CN(C)C=O>[F:38][C:36]([F:37])([F:39])[C:33]1[CH:34]=[CH:35][C:30]([O:29][C:26]2[CH:27]=[CH:28][C:23]([O:22][C:20]([N:8]3[CH2:9][CH2:10][CH:5]([N:4]([CH:1]4[CH2:3][CH2:2]4)[CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=4[F:18])[CH2:6][CH2:7]3)=[O:21])=[CH:24][CH:25]=2)=[N:31][CH:32]=1

Participants

5

Reactant 3

HCID 7912DiisopropylamineHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 22047808HCID 22047808, compound

Product 1

HCID 69517606HCID 69517606, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title product was prepared from cyclopropyl-(2-fluoro-benzyl)-piperidin-4-yl-amine and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, 3 equivalent of diisopropylamine was added, solvent: dimethylformamide. The crude reaction mixture was evaporated without addition of acetic acid, preparative HPLC (method C) (60%, colourless oil). HPLC-MS m/z=(M+1), Rt: 3.02 min.

Workup

  1. additionwas added
  2. customThe crude reaction mixture
  3. customwas evaporated without addition of acetic acid, preparative HPLC (method C) (60%, colourless oil)

Sources & evidence

ORD record
ord-cc10c9c9bda546648bcf2c3cf176c2fa
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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