Methyl Acrylate → 3-[4-(Methyl-phenyl-carbamoyloxy)-phenyl]-acrylic Acid methyl Ester

HRID 1180035Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:6])[CH:4]=[CH2:5].CN(C1CCCCC1)C1CCCCC1.I[C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29](=[O:38])[N:30]([CH3:37])[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:24][CH:23]=1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C>[CH3:1][O:2][C:3](=[O:6])[CH:4]=[CH:5][C:22]1[CH:23]=[CH:24][C:25]([O:28][C:29](=[O:38])[N:30]([CH3:37])[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:26][CH:27]=1

Participants

Conditions

Temperature: 70 °C

Procedure

Methylacrylate (1.2 mmol), N-methyldicyclohexylamine (1.2 mmol), Pd2(dba)3 (0.03 mmol), Pd(P(t-Bu)3)2 (0.06 mmol) and methyl-phenyl-carbamic acid 4-iodo-phenyl ester (1.0 mmol) were added to a Schlenk tube under nitrogen. The Schlenk tube was evacuated and refilled with nitrogen five times. Then dioxane (2 mL) was added and the reaction mixture was stirred at 70° C. for 8 h. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) giving the title compound in 70% yield as a yellow solid.

Workup

customThe Schlenk tube was evacuated
additionrefilled with nitrogen five times
additionThen dioxane (2 mL) was added
customThe crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane)

Sources & evidence

ORD record: ord-66f2eb7a92b3462597dc483d7b3bc941
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07279470B2

Reaction notes

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