Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester → Methyl-phenyl-carbamic Acid 4-(2-tetrazol-1-yl-ethyl)-phenyl Ester

HRID 1180070Notes

Reaction equation

HRID 1180070 reaction equation
O[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11](=[O:20])[N:12]([CH3:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:6][CH:5]=1.[NH:21]1[CH:25]=[N:24][N:23]=[N:22]1>>[N:21]1([CH2:2][CH2:3][C:4]2[CH:9]=[CH:8][C:7]([O:10][C:11](=[O:20])[N:12]([CH3:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:6][CH:5]=2)[CH:25]=[N:24][N:23]=[N:22]1

Participants

3

Reactant 2

HCID 69520342Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl EsterHCID 178418441HCID 178418441, compound

Product 1

HCID 69519158Methyl-phenyl-carbamic Acid 4-(2-tetrazol-1-yl-ethyl)-phenyl EsterYield 10%

Procedure

The title compound was prepared in 10% yield as an oil using methyl-phenyl-carbamic acid 4-(2-hydroxy-ethyl)-phenyl ester and tetrazole. NMR (400 MHz; CDCl3): δ 3.19 (t, 2H), 3.40 (br s, 3H), 3.47 (s, 1H), 4.61 (t, 2H), 6.98-7.07 (m, 4H), 7.25-7.42 (m, 5H), 8.26 (s, 1H); HPLC-MS: m/z=324.1 (M+1); Rt=3.36 min.

Sources & evidence

ORD record
ord-cb8ba2f209bb45bcabd91f7fea9de85c
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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