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HRID1180118

反应详情

EQUATION

反应方程式

HRID 1180118 的结构方程式

REACTANTS

反应物

2
结构：CCOC(C)=O.Cl
HCID21866389

未命名化合物

结构：CC(C)(C)OC(=O)N1C[C@@H](F)C[C@H]1C(N)=O
HCID49760522

2-Methyl-2-propanyl (2S,4S)-2-carbamoyl-4-fluoro-1-pyrrolidinecarboxylate

C10H17FN2O3

PRODUCTS

生成物

1
结构：Cl.NC(=O)[C@@H]1C[C@H](F)CN1
HCID45158917

(4S)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1)

C5H10ClFN2O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

(2S,4S)-1-(tert-Butoxycarbonyl)-2-carbamoyl-4-fluoropyrrolidine (122 g) was suspended in ethyl acetate (400 mL). While stirring this suspension under ice cooling, 4 mol/L hydrochloric acid-ethyl acetate (525 mL) was slowly added dropwise. After stirring at ice-cold temperature for 30 minutes and at room temperature for 3 hours, the precipitated crystal was collected by filtration to give the titled compound (85.9 g, white powder).

WORKUP

后处理

  1. stirringAfter stirring at ice-cold temperature for 30 minutes and at room temperature for 3 hours
  2. filtrationthe precipitated crystal was collected by filtration