[2-(1H-Pyrazol-1-yl)phenyl]boronic acid → HCID 10477788, compound

HRID 1180299Notes

Reaction equation

HRID 1180299 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[N:23]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2B(O)O)[CH:27]=[CH:26][CH:25]=[N:24]1>>[F:18][C:17]1[C:12]2[N:13]([C:9]([C:4]3[CH:5]=[CH:6][C:7]([F:8])=[C:2]([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[N:23]4[CH:27]=[CH:26][CH:25]=[N:24]4)[CH:3]=3)=[CH:10][N:11]=2)[CH:14]=[CH:15][C:16]=1[C:19]([OH:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 3296948[2-(1H-Pyrazol-1-yl)phenyl]boronic acidHCID 674866802-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-alpha]pyridin-7-yl]propan-2-ol

Product 1

HCID 10477788HCID 10477788, compoundYield 4%

Procedure

2-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]-propan-2-ol and 2-(pyrazol-1-yl)benzeneboronic acid were coupled in the same way as in Example 30 to give 2-{8-fluoro-3-[2-fluoro-2′-(pyrazol-1-yl)biphenyl-5-yl]imidazo[1,2-α]pyridin-7-yl}propan-2-ol as an off-white solid (5 mg, 4%): m/z (ES+) 431 [MH+].

Sources & evidence

ORD record
ord-1bea4adcb0a54848801c0f03a49db09c
Source dataset
uspto-grants-2007_10
Patent number
US07279580B2

Reaction notes

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