2-(5-Chloro-2-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane → HCID 9979330, compound

HRID 1180307Notes

Reaction equation

HRID 1180307 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([F:38])=[C:28](B2OCC(C)(C)CO2)[CH:29]=1>>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([F:38])=[C:26]([C:2]2[CH:3]=[C:4]([C:9]3[N:13]4[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]4=[N:11][CH:10]=3)[CH:5]=[CH:6][C:7]=2[F:8])[CH:25]=1

Participants

3

Reactant 2

HCID 179648342-(5-Chloro-2-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinaneHCID 674866802-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-alpha]pyridin-7-yl]propan-2-ol

Product 1

HCID 9979330HCID 9979330, compoundYield 3%

Procedure

2-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]-propan-2-ol and 2-(5-chloro-2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane were coupled in the same way as in Example 30 to give 2-[3-(5′-chloro-2,2′-difluorobiphenyl-5-yl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]propan-2-ol as an off-white solid (6 mg, 3%): m/z (ES+) 417 [MH+].

Sources & evidence

ORD record
ord-b6012c8501eb45fe9ad78c0a0fbbdd8c
Source dataset
uspto-grants-2007_10
Patent number
US07279580B2

Reaction notes

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