HCID 17964831, compound → HCID 10250810, compound

HRID 1180308Notes

Reaction equation

HRID 1180308 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]3=[N:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].CC1(C)COB([C:30]2[CH:31]=[CH:32][C:33]([F:38])=[C:34]([CH:37]=2)[C:35]#[N:36])OC1>>[F:38][C:33]1[CH:32]=[CH:31][C:30]([C:2]2[CH:3]=[C:4]([C:9]3[N:13]4[CH:14]=[CH:15][C:16]([C:19]([OH:22])([CH3:21])[CH3:20])=[C:17]([F:18])[C:12]4=[N:11][CH:10]=3)[CH:5]=[CH:6][C:7]=2[F:8])=[CH:37][C:34]=1[C:35]#[N:36]

Participants

3

Reactant 2

HCID 17964831HCID 17964831, compoundHCID 674866802-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-alpha]pyridin-7-yl]propan-2-ol

Product 1

HCID 10250810HCID 10250810, compoundYield 5%

Procedure

2-[3-(3-Chloro-4-fluorophenyl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]-propan-2-ol and 5-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-2-fluorobenzonitrile were coupled in the same way as in Example 30 to give 4,2′-difluoro-5′-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-α]pyridin-3-yl]biphenyl-3-carbonitrile as an off-white solid (9 mg, 5%): m/z (ES+) 408 [MH+].

Sources & evidence

ORD record
ord-2f210314561d454ebaee7d2cfccb227d
Source dataset
uspto-grants-2007_10
Patent number
US07279580B2

Reaction notes

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