1-(5-Bromo-2-fluorophenyl)pyrrolidin-2-one → 1-[2-Fluoro-5-(8-fluoro-7-trifluoromethylimidazo[1,2-alpha]pyridin-3-yl)-phenyl]pyrrolidin-2-one
Reaction equation
[F:1][C:2]1[C:3]2[N:4]([CH:12]=[CH:13][N:14]=2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].Br[C:16]1[CH:17]=[CH:18][C:19]([F:28])=[C:20]([N:22]2[CH2:26][CH2:25][CH2:24][C:23]2=[O:27])[CH:21]=1>>[F:28][C:19]1[CH:18]=[CH:17][C:16]([C:12]2[N:4]3[CH:5]=[CH:6][C:7]([C:8]([F:9])([F:10])[F:11])=[C:2]([F:1])[C:3]3=[N:14][CH:13]=2)=[CH:21][C:20]=1[N:22]1[CH2:26][CH2:25][CH2:24][C:23]1=[O:27]Participants
3
Procedure
8-Fluoro-7-trifluoromethylimidazo[1,2-α]pyridine was coupled to 1-(5-bromo-2-fluorophenyl)pyrrolidin-2-one as described in Example 6 to give 1-[2-fluoro-5-(8-fluoro-7-trifluoromethylimidazo[1,2-α]pyridin-3-yl)-phenyl]pyrrolidin-2-one as a white solid (90 mg, 24%): m/z (ES+) 382 [MH+].
Sources & evidence
- ORD record
- ord-363f1f9892564a98baf83ae3d96c49ed
- Source dataset
- uspto-grants-2007_10
- Patent number
- US07279580B2
Reaction notes
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