HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Bromo-2-fluorophenyl)pyrrolidin-2-one → 1-[2-Fluoro-5-(8-fluoro-7-trifluoromethylimidazo[1,2-alpha]pyridin-3-yl)-phenyl]pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Bromo-2-fluorophenyl)pyrrolidin-2-one | HCID 17964833 | — |
| Reactant | 8-Fluoro-7-(trifluoromethyl)imidazo[1,2-a]pyridine | HCID 67486324 | — |
| Product | 1-[2-Fluoro-5-(8-fluoro-7-trifluoromethylimidazo[1,2-alpha]pyridin-3-yl)-phenyl]pyrrolidin-2-one | HCID 9977119 | 24% |
Reaction Steps
8-Fluoro-7-trifluoromethylimidazo[1,2-α]pyridine was coupled to 1-(5-bromo-2-fluorophenyl)pyrrolidin-2-one as described in Example 6 to give 1-[2-fluoro-5-(8-fluoro-7-trifluoromethylimidazo[1,2-α]pyridin-3-yl)-phenyl]pyrrolidin-2-one as a white solid (90 mg, 24%): m/z (ES+) 382 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07279580B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-363f1f9892564a98baf83ae3d96c49ed |
| Source note | uspto-grants-2007_10 |