Hydroxyamine hydrochloride → HCID 136338598, compound

HRID 1180344Notes

Reaction equation

HRID 1180344 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[CH:8]=O.Cl.[NH2:18][OH:19]>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[CH:8]=[N:18][OH:19]

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 58978546HCID 58978546, compound

Product 1

HCID 136338598HCID 136338598, compound

Procedure

The title compound was prepared by reacting 3-fluoro-4′-hydroxy-1,1′-biphenyl-4-carbaldehyde (154 mg, 0.713 mmol) with hydroxylamine hydrochloride (99 mg, 1.43 mmol) according to Method C to yield 156 mg (95%) of yellowish solid: mp 181-183° C.; 1H NMR (DMSO-d6): δ 6.84-6.87 (2H, m), 7.48-7.53 (2H, m), 7.57-7.60 (2H, m), 7.76 (1H, t, J=8.14 Hz), 8.22 (1H, s), 9.74 (1H, s), 11.56 (1H, s); MS (ESI) m/z 230 (M−H)−, 232 (M+H)+.

Sources & evidence

ORD record
ord-931055ce0263403ab9e613a259c8eab2
Source dataset
uspto-grants-2007_10
Patent number
US07279600B2

Reaction notes

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