Hydroxyamine hydrochloride → HCID 136338606, compound

HRID 1180355Notes

Reaction equation

HRID 1180355 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([CH:9]=O)[CH:5]=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.Cl.[NH2:19][OH:20]>>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([CH:9]=[N:19][OH:20])[CH:5]=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 58978537HCID 58978537, compound

Product 1

HCID 136338606HCID 136338606, compound

Procedure

The title compound was prepared by reacting 48 (140 mg, 0.526 mmol) with hydroxylamine hydrochloride (110 mg, 1.58 mmol) according to method F to yield 148 mg (100%) of off white solid: mp 208-210° C.; 1H NMR (DMSO-d6): δ 6.84-6.87 (2H, m), 7.26-7.29 (2H, m), 7.36 (1H, d, J=7.94 Hz). 7.80 (1H, d, J=8.20 Hz), 8.41 (1H, s), 9.72 (1H, s), 11.83 (1H, s); MS (ESI) m/z 280/282/284 (M−H)−, 282/284/286 (M+H)+.

Workup

  1. customto yield 148 mg (100%) of off white solid

Sources & evidence

ORD record
ord-a3f8072b56d24ed8bc694736308132ed
Source dataset
uspto-grants-2007_10
Patent number
US07279600B2

Reaction notes

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