4-Bromobenzaldehyde → (4-Bromophenyl)(thiazol-2-yl)methanol

HRID 1180402Notes

Reaction equation

Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[Br:7][C:8]1[CH:15]=[CH:14][C:11]([CH:12]=[O:13])=[CH:10][CH:9]=1>>[Br:7][C:8]1[CH:15]=[CH:14][C:11]([CH:12]([C:2]2[S:3][CH:4]=[CH:5][N:6]=2)[OH:13])=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 707414-Bromobenzaldehyde

HCID 764302-Bromothiazole

Product 1

HCID 14949088(4-Bromophenyl)(thiazol-2-yl)methanol

Procedure

Using the same protocol as described in example 22, step 1, 2-bromothiazole (451 μL, 5.0 mmol) was added to 4-bromobenzaldehyde (1.018 g, 5.5 mmol). The crude residue was chromatographed on silica gel using 50% ethyl acetate in hexanes to afford the title compound.

Workup

customThe crude residue was chromatographed on silica gel using 50% ethyl acetate in hexanes

Sources & evidence

ORD record: ord-d2df9a5693384c599a9d68b098ef07fb
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07279478B2

Reaction notes

Loading…