18820-83-2 → HCID 86605390, compound

HRID 1180425Notes

Reaction equation

HRID 1180425 reaction equation
[C:1]([CH2:3][NH:4][C:5](=[O:31])[C@@H:6]([O:11][C@H:12]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)=[CH:15][CH:14]=1)[CH2:7][CH:8]([CH3:10])[CH3:9])#[N:2].[I-:32].[NH+]1C=CC=C[CH:34]=1>C(OCC)C>[I-:32].[C:1]([CH2:3][NH:4][C:5]([C@@H:6]([O:11][C@H:12]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[N+:21]([CH3:34])[CH:22]=[CH:23][CH:24]=2)=[CH:15][CH:14]=1)[CH2:7][CH:8]([CH3:10])[CH3:9])=[O:31])#[N:2]

Participants

4

Reactant 2

HCID 2186351518820-83-2HCID 86605392HCID 86605392, compound

Product 1

HCID 86605390HCID 86605390, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using the same procedure as described for example 36 step 3 (2S)-N-(cyanomethyl)-4-methyl-2-{[(R)-phenyl(4-pyridin-3-ylphenyl)methyl]oxy}pentanamide (150 mg, 0.36 mmol) was converted to its pyridinium iodide salt. The salt was swished with diethyl ether (20 mL) for 18 h and the title compound was filtered off as an amorphous solid.

Workup

  1. filtrationthe title compound was filtered off as an amorphous solid

Sources & evidence

ORD record
ord-e30aefd40606435fa8c362933bc42027
Source dataset
uspto-grants-2007_10
Patent number
US07279478B2

Reaction notes

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