Dimethylamine, hydrochloride → HCID 86605401, compound

HRID 1180433Notes

Reaction equation

HRID 1180433 reaction equation
[C:1]([CH2:3][NH:4][C:5]([C@@H:7]([O:12][CH:13]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:14]1[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=1)[CH2:8][CH:9]([CH3:11])[CH3:10])=[O:6])#[N:2].Cl.[CH3:30][NH:31][CH3:32]>CC(C)=O.C1(C)C=CC=CC=1>[C:1]([CH2:3][NH:4][C:5]([C@@H:7]([O:12][CH:13]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:14]1[CH:15]=[CH:16][C:17]([C:18]([N:31]([CH3:32])[CH3:30])=[O:19])=[CH:21][CH:22]=1)[CH2:8][CH:9]([CH3:11])[CH3:10])=[O:6])#[N:2]

Participants

4

Reactant 2

HCID 10473Dimethylamine, hydrochlorideHCID 10429855HCID 10429855, compound

Product 1

HCID 86605401HCID 86605401, compound

Reagents, catalysts & solvents 1

HCID 20247278Toluene acetoneSolvent

Procedure

Using the same coupling procedure as described for example 47, 4-[[((1S)-1-{[(cyanomethyl)amino]carbonyl}-3-methylbutyl)oxy](phenyl)methyl]benzoic acid (51 mg, 0.134 mmol) was reacted with dimethylamine hydrochloride (11 mg, 0.134 mmol, 1 eg) to give the title compound as an oil after chromatography with 25% acetone/toluene.

Sources & evidence

ORD record
ord-9da9b1b3bc3f4eb394fac4b738c8ab2f
Source dataset
uspto-grants-2007_10
Patent number
US07279478B2

Reaction notes

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