Acetone → HCID 69318184, compound

HRID 1180532Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)=[C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[C:16](=NOC)[CH2:15][CH2:14]3)[N:10]=1)=[O:5])[CH3:2].[ClH:29].CC(C)=[O:32]>O1CCOCC1>[ClH:29].[ClH:29].[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([C:23]2[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=2)=[C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[C:16](=[O:32])[CH2:15][CH2:14]3)[N:10]=1)=[O:5])[CH3:2]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of the product of Step 5 (1.0 g, 2.7 mmol) and 5M HCl (15 ml) in dioxane (30 ml)/acetone (30 ml) was heated to 100° C. for 3 hour. The mixture was cooled to room temperature and the solvent evaporated in vacuo. The residue was co-evaporated with acetone (2×20 ml) and ethanol/acetone (1:1, 20 ml) to give the title compound (1.0 g, 88%); MS(ES−) m/e 346 [M−H]−.

Workup

temperatureThe mixture was cooled to room temperature
customthe solvent evaporated in vacuo

Sources & evidence

ORD record: ord-2a39e206a9ce43a19f0cd8198b1036fb
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07282500B2

Reaction notes

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