Trifluoroacetic acid → HCID 58978922, compound

HRID 1180552Notes

Reaction equation

HRID 1180552 reaction equation
[CH3:1][C:2]1([CH3:30])[S:7][CH2:6][CH2:5][N:4]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]=[C:20]=[CH:21][CH3:22])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[C@H:3]1[C:23]([O:25]C(C)(C)C)=[O:24].FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:30][C:2]1([CH3:1])[S:7][CH2:6][CH2:5][N:4]([S:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH:19]=[C:20]=[CH:21][CH3:22])=[CH:15][CH:16]=2)(=[O:9])=[O:10])[C@H:3]1[C:23]([OH:25])=[O:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58978934HCID 58978934, compound

Product 1

HCID 58978922HCID 58978922, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product from Example 27 (200 mg, 0.44 mmol) in methylene chloride (4 mL) was added trifluoroacetic acid (1 mL) and the resulting mixture was stirred for 2 h at room temperature. The solvents were removed in vacuo and the residue was purified by silica gel column chromatagraphy to obtain the product (120 mg, 69%) as a white solid.

Workup

  1. customThe solvents were removed in vacuo
  2. customthe residue was purified by silica gel column chromatagraphy

Sources & evidence

ORD record
ord-3c3d95b6b8df4007882d70c0f2ba7657
Source dataset
uspto-grants-2007_10
Patent number
US07282496B2

Reaction notes

Loading…