HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-[(2-Benzoylamino-benzyl)-(4-methoxy-benzenesulfonyl)-amino]-acrylic acid methyl ester | HCID 18613026 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylic Acid Methyl Ester | HCID 18612738 | 92% |
Reaction Steps
The procedure of Example 35 was followed using the product from Example 34 (500 mg, 1.04 mmol) and sodium bicarbonate (114 mg, 1.35 mmoml) in methanol (5 ml) to give 460 mg (92%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07282496B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-ae071371034a49b2bfefde67b00b7921 |
| Source note | uspto-grants-2007_10 |