Sodium Bicarbonate → 1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylic Acid Methyl Ester

HRID 1180559Notes

Reaction equation

HRID 1180559 reaction equation
[CH3:1][O:2][C:3](=[O:34])[C:4]([N:6]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:26](=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[S:7]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)(=[O:9])=[O:8])=[CH2:5].C(=O)(O)[O-].[Na+]>CO>[CH3:1][O:2][C:3]([CH:4]1[N:6]([S:7]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[N:25]([C:26](=[O:33])[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:5]1)=[O:34]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 186130262-[(2-Benzoylamino-benzyl)-(4-methoxy-benzenesulfonyl)-amino]-acrylic acid methyl ester

Product 1

HCID 186127381-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylic Acid Methyl EsterYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure of Example 35 was followed using the product from Example 34 (500 mg, 1.04 mmol) and sodium bicarbonate (114 mg, 1.35 mmoml) in methanol (5 ml) to give 460 mg (92%) of the product.

Sources & evidence

ORD record
ord-ae071371034a49b2bfefde67b00b7921
Source dataset
uspto-grants-2007_10
Patent number
US07282496B2

Reaction notes

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