反应详情

Oxalyl chloride (1.5 equiv.) is added drop wise to a slurry of 8-Bromo-[1,6]naphthyridine-2-carboxylic acid (1 equiv., in 20 mL DMF) at 0° C. (ice bath) and stirred for 30 minutes. The reaction mixture is removed from the ice bath, stirred at room temperature for 3 h and then concentrated in vacuo to give a greenish colored solid, which is used immediately without further purification.

1. customThe reaction mixture is removed from the ice bath
2. stirringstirred at room temperature for 3 h
3. concentrationconcentrated in vacuo
4. customto give a greenish colored solid, which
5. customis used immediately without further purification