Hydrochloric Acid → HCID 23435828, compound

HRID 1180584Notes

Reaction equation

HRID 1180584 reaction equation
C1(=O)[N:5]([O:6][CH:7]2[CH2:12][CH2:11][O:10][C:8]2=[O:9])C(=O)C2=CC=CC=C12.[ClH:19]>>[ClH:19].[NH2:5][O:6][CH:7]1[CH2:12][CH2:11][O:10][C:8]1=[O:9]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 135771142-[(2-Oxooxolan-3-yl)oxy]-1H-isoindole-1,3(2H)-dione

Product 1

HCID 23435828HCID 23435828, compound

Procedure

α-Phthalimidooxy-γ-butyrolactone (1.0 g, 4 mmol) was added to hydrochloric acid (1 M, 10 mL) at reflux. After 5 min. at reflux for 5 min and the reaction was cooled down on an ice bath and filtered. The filtrate was evaporated to dryness. Toluene was added and residual water removed azeotropic distillation. 0.75 g of the desired material was obtained.

Workup

  1. temperatureat reflux
  2. temperatureAfter 5 min. at reflux for 5 min
  3. temperaturethe reaction was cooled down on an ice bath
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness
  6. additionToluene was added
  7. distillationresidual water removed azeotropic distillation

Sources & evidence

ORD record
ord-ad345c01e9fa40e8a0235fbc898493d6
Source dataset
uspto-grants-2007_10
Patent number
US07282511B2

Reaction notes

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