3,4-Difluorobenzeneboronic acid → CID 23571065

Participants

Role	Name	HCID	Charge
Reactant	3,4-Difluorobenzeneboronic acid	HCID 2734337	—
Reactant	[6s,9r,11r]2',3',4',5,5',6,7,8,9,10-Decahydro-2-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-5'-(2,2,2-trifluoroethyl)spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazole]1',1'-dioxide	HCID 23571079	—
Reactant	HCID 178418934	HCID 178418934	—
Product	CID 23571065	HCID 23571065	—

Reaction Steps

Prepared from 4-bromo-1H-imidazole, 3,4-difluorophenylboronic acid and homochiral boronate from Example 24 Step 1 following the procedures in Example 76 Steps 1 and 2. □ (1H, 400 MHz, CDCl3) 1.18-1.24 (2H, m), 1.70-1.73 (2H, m), 2.43-2.49 (2H, m), 2.69-2.81 (2H, m), 3.20-3.26 (2H, m), 3.44 (2H, s), 3.68 (2H, q, J=8.7 Hz), 4.72 (1H, s), 7.13 (1H, d, J=7.8 Hz), 7.19-7.22 (1H, m) 7.28-7.35 (2H, m), 7.48 (1H, d, J=1 Hz), 7.54 (1H, dd, J=7.7, 2 Hz), 7.61 (1H, s), 7.83 (1H, d, J=1 Hz). MS (ES+) 539 ([MH]+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07282513B2
Source dataset	uspto-grants-2007_10
ORD ID	ord-0fe1f10fc1dc4a209134969ea886d436
Source note	uspto-grants-2007_10