Hydrochloric Acid → Bepotastine

In 760 ml of ethanol was dissolved 126.0 g (0.302 mol) of ethyl (S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]-piperidino]butanoate obtained according to Reference example 3(1), and then 120.8 ml of a 5N aqueous sodium hydroxide solution was added to the mixture and the mixture was allowed to stand at room temperature overnight. After confirming disappearance of the starting materials, the mixture was neutralized by adding 121.1 ml of a 5N hydrochloric acid. After the precipitated crystals were removed by filtration, the reaction mixture was concentrated under reduced pressure. To the residue was added 600 ml of methyl acetate, and the solution was again concentrated under reduced pressure. The residue was dissolved in 600 ml of dichloromethane and dried over anhydrous magnesium sulfate sufficiently. Insolubles were removed by filtration, the filtrate was concentrated to afford the desired compound as an orange syrupy product (125.3 g). When the syrupy product was further dried under reduced pressure, it became a foamy product (120.2 g).

1. customobtained
2. customAfter the precipitated crystals were removed by filtration
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. additionTo the residue was added 600 ml of methyl acetate
5. concentrationthe solution was again concentrated under reduced pressure
6. dissolutionThe residue was dissolved in 600 ml of dichloromethane
7. dry with materialdried over anhydrous magnesium sulfate sufficiently
8. customInsolubles were removed by filtration
9. concentrationthe filtrate was concentrated

ORD record

ord-385605d0c0184058b94f3048f15afef9

Source dataset

uspto-grants-2007_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07282589B2