5-Chloro-3-phenyl-1,2,4-thiadiazole → (1-{[(3-Phenyl-1,2,4-thiadiazol-5-yl)oxy]methyl}cyclobutyl)methanol

HRID 1180779Notes

Reaction equation

HRID 1180779 reaction equation
[OH:1][CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]1.Cl[C:10]1[S:14][N:13]=[C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:11]=1>>[C:15]1([C:12]2[N:11]=[C:10]([O:1][CH2:2][C:3]3([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]3)[S:14][N:13]=2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 322625-Chloro-3-phenyl-1,2,4-thiadiazoleHCID 4498243Cyclobutane-1,1-diyldimethanol

Product 1

HCID 11460078(1-{[(3-Phenyl-1,2,4-thiadiazol-5-yl)oxy]methyl}cyclobutyl)methanol

Procedure

The title compound was prepared using the same experimental procedure as in example 25a from [1-(hydroxymethyl)cyclobutyl]methanol and 5-chloro-3-phenyl-1,2,4-thiadiazole. 1H NMR (300 MHz, CDCl3) δ 8.10 (m, 2H), 7.39 (m, 3H), 4.63 (s, 2H), 3.62 (d, J=6 Hz, 2H), 2.71 (t, J=6 Hz, 1H), 1.88-1.97 (m, 6H). GC-MS m/z 277 (M+H).

Sources & evidence

ORD record
ord-5ca64188b34940c58cd007128a1ec0c6
Source dataset
uspto-grants-2007_10
Patent number
US07282512B2

Reaction notes

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