Cyclobutane-1,1-diyldimethanol → [1-({[4-(4-Methylphenyl)-1,3-thiazol-2-yl]oxy}methyl)cyclobutyl]methanol

HRID 1180783Notes

Reaction equation

HRID 1180783 reaction equation
[OH:1][CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]1.Cl[C:10]1[S:11][CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[N:14]=1>>[CH3:21][C:18]1[CH:19]=[CH:20][C:15]([C:13]2[N:14]=[C:10]([O:1][CH2:2][C:3]3([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4]3)[S:11][CH:12]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 4498243Cyclobutane-1,1-diyldimethanolHCID 124714262-Chloro-4-(4-methylphenyl)thiazole

Product 1

HCID 11150432[1-({[4-(4-Methylphenyl)-1,3-thiazol-2-yl]oxy}methyl)cyclobutyl]methanol

Procedure

The title compound was prepared using the same experimental procedure as in example 25a from [1-(hydroxymethyl)cyclobutyl]methanol and 2-chloro-4-(4-methylphenyl)-1,3-thiazole. 1H NMR (300 MHz, CDCl3) δ 7.61 (d, J=8 Hz, 2H), 7.16 (d, J=8 Hz, 2H), 6.78 (s, 1H), 4.62 (s, 2H), 3.77 (t, J=7 Hz, 1H), 3.60 (d, J=7 Hz, 2H), 2.35 (s, 3H), 2.04-1.90 (m, 6H). GC-MS m/z 290 (M+H).

Sources & evidence

ORD record
ord-9373bea1dc7041569c150d4f74c2f7be
Source dataset
uspto-grants-2007_10
Patent number
US07282512B2

Reaction notes

Loading…