2-{1-[(Benzyloxy)methyl]cyclobutyl}ethanethioamide → {1-[(4-Methyl-1,3-thiazol-2-yl)methyl]cyclobutyl}methanol

HRID 1180787Notes

Reaction equation

HRID 1180787 reaction equation
C([O:8][CH2:9][C:10]1([CH2:14][C:15](=[S:17])[NH2:16])[CH2:13][CH2:12][CH2:11]1)C1C=CC=CC=1.Br[CH2:19][C:20](=O)[CH2:21]C(F)(F)F>>[CH3:21][C:20]1[N:16]=[C:15]([CH2:14][C:10]2([CH2:9][OH:8])[CH2:11][CH2:12][CH2:13]2)[S:17][CH:19]=1

Participants

3

Reactant 2

HCID 112651762-{1-[(Benzyloxy)methyl]cyclobutyl}ethanethioamideHCID 211002021-Bromo-4,4,4-trifluoro-2-butanone

Product 1

HCID 58979694{1-[(4-Methyl-1,3-thiazol-2-yl)methyl]cyclobutyl}methanol

Procedure

The title compound was prepared using the same experimental procedure as in examples 18f and 18g from 2-{1-[(benzyloxy)methyl]cyclobutyl}ethanethioamide and 1-bromo-4,4,4-trifluoro-2-butanone. 1H NMR (300 MHz, CDCl3) δ 7.25 (s, 1H), 3.35 (s, 2H), 2.82 (br s, 2H), 2.02-1.91 (m, 6H).

Sources & evidence

ORD record
ord-fadf44fe503d4920ac461fde20fa6ea6
Source dataset
uspto-grants-2007_10
Patent number
US07282512B2

Reaction notes

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