2,4-Dichloropyrimidine → HCID 11749035, compound

HRID 1180793Notes

Reaction equation

HRID 1180793 reaction equation
[Si:1]([O:8][CH2:9][C:10]1([CH2:14][CH2:15][CH2:16][OH:17])[CH2:13][CH2:12][CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[Cl:18][C:19]1[N:24]=[C:23](Cl)[CH:22]=[CH:21][N:20]=1>>[Si:1]([O:8][CH2:9][C:10]1([CH2:14][CH2:15][CH2:16][O:17][C:21]2[CH:22]=[CH:23][N:24]=[C:19]([Cl:18])[N:20]=2)[CH2:11][CH2:12][CH2:13]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 11391263HCID 11391263, compound

Product 1

HCID 11749035HCID 11749035, compound

Procedure

The title compound was prepared from 3-[1-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclobutyl]-1-propanol and 2,4-dichloropyrimidine using the same experimental procedure as in example 25a. 1H NMR (300 MHz, CDCl3) δ 8.23 (d, J=6 Hz, 1H), 6.59 (d, J=6 Hz, 1H), 4.33 (t, J=6 Hz, 2H), 3.44 (s, 2H), 1.81-1.51 (m, 8H), 1.21 (m, 2H), 0.84 (s, 9H), −0.002 (s, 6H). GC-MS m/z 371 (M+H).

Sources & evidence

ORD record
ord-76ecc7fedfa047a281c30a6b51b5f3eb
Source dataset
uspto-grants-2007_10
Patent number
US07282512B2

Reaction notes

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