Dichloromethane → HCID 68995203, compound

HRID 1180950Notes

Reaction equation

HRID 1180950 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:37]([S:38]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)(=[O:40])=[O:39])[C:12]3=[N:13][CH:14]=[CH:15][C:16]([C:17]4[C:18]([C:23]5[CH:28]=[CH:27][C:26]([NH:29][C:30]([N:32]6[CH2:36][CH2:35][CH2:34][CH2:33]6)=[O:31])=[CH:25][CH:24]=5)=[N:19][N:20]([CH3:22])[CH:21]=4)=[C:11]3[CH:10]=2)=[CH:5][CH:4]=1)=O.[CH2:47]([NH:49][CH2:50][CH2:51][OH:52])[CH3:48].ClCCl>ClC(Cl)C>[CH2:47]([N:49]([CH2:1][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:37]([S:38]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)(=[O:39])=[O:40])[C:12]3=[N:13][CH:14]=[CH:15][C:16]([C:17]4[C:18]([C:23]5[CH:24]=[CH:25][C:26]([NH:29][C:30]([N:32]6[CH2:36][CH2:35][CH2:34][CH2:33]6)=[O:31])=[CH:27][CH:28]=5)=[N:19][N:20]([CH3:22])[CH:21]=4)=[C:11]3[CH:10]=2)=[CH:5][CH:4]=1)[CH2:50][CH2:51][OH:52])[CH3:48]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 80722-(Ethylamino)ethanolHCID 86613331HCID 86613331, compound

Product 1

HCID 68995203HCID 68995203, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure described in Intermediate 101 using N-(4-{4-[2-(4-formylphenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1H-pyrazol-3-yl}phenyl)-1-pyrrolidinecarboxamide and 2-(ethylamino)ethanol in dichloroethane (instead of dichloromethane) provided the title compound. ESMS [M+H]+: 704.6.

Sources & evidence

ORD record
ord-4582b61f71784da1bdae75c7dbb352e5
Source dataset
uspto-grants-2007_10
Patent number
US07282588B2

Reaction notes

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