1-Methylpiperazine → 5-Bromo-2-(4-methylpiperazin-1-yl)pyrimidine

HRID 1180956Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)=[N:6][CH:7]=1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 6066655-Bromo-2-chloropyrimidine

Product 1

HCID 41281585-Bromo-2-(4-methylpiperazin-1-yl)pyrimidine

Procedure

Following the procedure described for Intermediate 234 using 5-bromo-2-chloropyrimidine and N-methylpiperazine provided the title compound. ESMS [M+H]+: 257.0/259.0.

Sources & evidence

ORD record: ord-fca9cc8c8c8e49579f0c2b146e2eb7d7
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07282588B2

Reaction notes

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