Toluene-4-sulfonic acid 2-[2-(4-bromophenyl)-5-methyloxazol-4-yl]ethyl ester → HCID 69232919, compound

HRID 1181061Notes

Reaction equation

HRID 1181061 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:26])=[C:11]([CH2:13][CH2:14][O:15]S(C3C=CC(C)=CC=3)(=O)=O)[N:12]=2)=[CH:4][CH:3]=1.[C:27]([O:31][C:32](=[O:50])[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38](O)=[CH:37][C:36]=1[CH2:42][NH:43]C(OC(C)C)=O)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32](=[O:50])[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:15][CH2:14][CH2:13][C:11]2[N:12]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=3)[O:9][C:10]=2[CH3:26])=[CH:37][C:36]=1[CH:42]([C:32]([O:31][CH:27]([CH3:29])[CH3:28])=[O:50])[NH2:43])([CH3:28])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 58979135Toluene-4-sulfonic acid 2-[2-(4-bromophenyl)-5-methyloxazol-4-yl]ethyl esterHCID 589794703-[4-Hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester

Product 1

HCID 69232919HCID 69232919, compoundYield 127.1%

Procedure

Toluene-4-sulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester (5.06 g, 11.6 mmol) and 3-[4-hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester (3.01 g, 8.92 mmol) were coupled using Standard procedure A to give the title compound as a white solid (3.41 g, 64%). MS [ES] m/z 601.603 (M+H).

Sources & evidence

ORD record
ord-1adc0363e3484812ade7299ec5239026
Source dataset
uspto-grants-2007_10
Patent number
US07282501B2

Reaction notes

Loading…