HRID1181061

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(S(=O)(=O)OCCc2nc(-c3ccc(Br)cc3)oc2C)cc1

HCID58979135

未命名化合物

结构：CC(C)OC(=O)NCc1cc(O)ccc1CCC(=O)OC(C)(C)C

HCID58979470

未命名化合物

PRODUCTS

生成物

结构：Cc1oc(-c2ccc(Br)cc2)nc1CCOc1ccc(CCC(=O)OC(C)(C)C)c(C(N)C(=O)OC(C)C)c1

HCID69232919

未命名化合物

收率 127.1%

PROCEDURE

实验过程

Toluene-4-sulfonic acid 2-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-ethyl ester (5.06 g, 11.6 mmol) and 3-[4-hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester (3.01 g, 8.92 mmol) were coupled using Standard procedure A to give the title compound as a white solid (3.41 g, 64%). MS [ES] m/z 601.603 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1adc0363e3484812ade7299ec5239026
来源数据集: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07282501B2
来源说明: uspto-grants-2007_10

反应 SMILES

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:26])=[C:11]([CH2:13][CH2:14][O:15]S(C3C=CC(C)=CC=3)(=O)=O)[N:12]=2)=[CH:4][CH:3]=1.[C:27]([O:31][C:32](=[O:50])[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38](O)=[CH:37][C:36]=1[CH2:42][NH:43]C(OC(C)C)=O)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32](=[O:50])[CH2:33][CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:15][CH2:14][CH2:13][C:11]2[N:12]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=3)[O:9][C:10]=2[CH3:26])=[CH:37][C:36]=1[CH:42]([C:32]([O:31][CH:27]([CH3:29])[CH3:28])=[O:50])[NH2:43])([CH3:28])([CH3:29])[CH3:30]