2-Bromopyridine → HCID 10231285, compound

HRID 1181070Notes

Reaction equation

C([O:5][C:6](=[O:39])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=3)[O:21][C:22]=2[CH3:23])=[CH:11][C:10]=1[CH2:31][NH:32][C:33]([O:35][CH:36]([CH3:38])[CH3:37])=[O:34])(C)(C)C.Br[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=1>>[CH:36]([O:35][C:33]([NH:32][CH2:31][C:10]1[CH:11]=[C:12]([O:15][CH2:16][CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:29]=[CH:28][C:27]([O:30][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=4)=[CH:26][CH:25]=3)[O:21][C:22]=2[CH3:23])[CH:13]=[CH:14][C:9]=1[CH2:8][CH2:7][C:6]([OH:5])=[O:39])=[O:34])([CH3:38])[CH3:37]

Participants

Reactant 2

HCID 79732-Bromopyridine

HCID 136104127HCID 136104127, compound

Product 1

HCID 10231285HCID 10231285, compound

Procedure

3-[4-{2-[2-(4-hydroxy-phenyl)-5-methyl-oxazol-4-yl]-ethoxy}-2-(isopropoxy-carbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester (Example 406) was reacted with 2-bromopyridine by the procedure in Example 397 to give the title compound. MS (ES) m/z 560 (M+1).

Sources & evidence

ORD record: ord-3df91865dc874a49b8c59b6bcf5b4686
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07282501B2

Reaction notes

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