3-[4-Hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester → 3-(2-(Isopropoxycarbonylamino-methyl)-4-{2-[5-methyl-2-(4-nitro-phenyl)-oxazol-4-yl]-ethoxy}-phenyl)-propionic acid tert-butyl ester

HRID 1181071Notes

Reaction equation

HRID 1181071 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:16][CH2:17][O:18]S(C1C=CC(C)=C([N+]([O-])=O)C=1)(=O)=O.[C:32]([O:36][C:37](=[O:55])[CH2:38][CH2:39][C:40]1[CH:45]=[CH:44][C:43](O)=[CH:42][C:41]=1[CH2:47][NH:48][C:49]([O:51][CH:52]([CH3:54])[CH3:53])=[O:50])([CH3:35])([CH3:34])[CH3:33]>>[C:32]([O:36][C:37](=[O:55])[CH2:38][CH2:39][C:40]1[CH:45]=[CH:44][C:43]([O:18][CH2:17][CH2:16][C:3]2[N:4]=[C:5]([C:7]3[CH:8]=[CH:9][C:10]([N+:13]([O-:15])=[O:14])=[CH:11][CH:12]=3)[O:6][C:2]=2[CH3:1])=[CH:42][C:41]=1[CH2:47][NH:48][C:49]([O:51][CH:52]([CH3:53])[CH3:54])=[O:50])([CH3:35])([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 589794703-[4-Hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl esterHCID 589794954-Methyl-3-nitro-benzenesulfonic acid 2-[5-methyl-2-(4-nitro-phenyl)-oxazol-4-yl]-ethyl ester

Product 1

HCID 589793583-(2-(Isopropoxycarbonylamino-methyl)-4-{2-[5-methyl-2-(4-nitro-phenyl)-oxazol-4-yl]-ethoxy}-phenyl)-propionic acid tert-butyl ester

Procedure

4-Methyl-3-nitro-benzenesulfonic acid 2-[5-methyl-2-(4-nitro-phenyl)-oxazol-4-yl]-ethyl ester (Preparation 7) and 3-[4-hydroxy-2-(isopropoxycarbonylamino-methyl)-phenyl]-propionic acid tert-butyl ester were coupled by Standard procedure A to give the title compound.

Sources & evidence

ORD record
ord-c547cf59481e489e993c50805e0d2c91
Source dataset
uspto-grants-2007_10
Patent number
US07282501B2

Reaction notes

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