Sodium Hydroxide → HCID 42637648, compound

HRID 1181197Notes

Reaction equation

[CH2:1]([N:8]1[C:16](Br)=[N:15][C:14]2[C:9]1=[N:10][CH:11]=[N:12][C:13]=2[NH2:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19][CH2:20][CH2:21][P:22](=[O:25])([O-:24])[O-:23].[OH-].[Na+]>C(O)C.O>[CH2:1]([N:8]1[C:16]([NH:19][CH2:20][CH2:21][P:22]([OH:25])([OH:24])=[O:23])=[N:15][C:14]2[C:9]1=[N:10][CH:11]=[N:12][C:13]=2[NH2:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 110 °C

Procedure

A mixture of N9-benzyl-8-bromoadenine (1 mmol), aminoethylphosphonate (2 mmol), and sodium hydroxide (2 mmol) in ethanol-water in a sealed tube was warmed at 110° C. under nitrogen. After 24 h the cooled reaction mixture was purified through preparative HPLC to give N9-benzyl-8-(2-phosphonoethylamino)adenine (3.1). Exact mass calculated for C14H17N6O3P+H+: 349.1178. Found: 349.1180.

Workup

customAfter 24 h the cooled reaction mixture
customwas purified through preparative HPLC

Sources & evidence

ORD record: ord-f4ee8d3398ac4bba899695796004d590
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07285543B2

Reaction notes

Loading…