Hydrazine hydrate (1:1) → HCID 21960238, compound

HRID 1181271Notes

Reaction equation

HRID 1181271 reaction equation
[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([Cl:11])[C:5]=2[S:4][CH:3]=1.O.[NH2:13][NH2:14]>C(O)C>[ClH:11].[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([NH:13][NH2:14])[C:5]=2[S:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 166552667-Bromo-4-chlorothieno[3,2-d]pyrimidine

Product 1

HCID 21960238HCID 21960238, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 7-bromo4-chlorothieno[3,2-d]pyrimidine (159, 80 mg, 0.32 mmol) and hydrazine monohydrate (0.2 mL, 4.1 mmol) in ethanol (1.3 mL) was heated at reflux for 2 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (57 mg, 73% yield) as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 hour
  3. filtrationthe solid product was collected by vacuum filtration

Sources & evidence

ORD record
ord-3f9b79886cdb44c08eca097106224dc7
Source dataset
uspto-grants-2007_10
Patent number
US07285556B2

Reaction notes

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