Hydrazine hydrate (1:1) → HCID 21960248, compound

HRID 1181277Notes

Reaction equation

HRID 1181277 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:14][C:13]3[C:12]([Cl:15])=[N:11][CH:10]=[N:9][C:8]=3[CH:7]=2)=[CH:2]1.O.[NH2:17][NH2:18]>C(O)C>[ClH:15].[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:14][C:13]3[C:12]([NH:17][NH2:18])=[N:11][CH:10]=[N:9][C:8]=3[CH:7]=2)=[CH:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21960234HCID 21960234, compound

Product 1

HCID 21960248HCID 21960248, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 6-(3-thienyl)4-chlorothieno[3,2-d]pyrimidine (220, 65 mg, 0.26 mmol) and hydrazine monohydrate (0.1 mL, 2.1 mmol) in ethanol (1 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (6-(3-thienyl)thieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (48 mg, 66% yield) as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1 hour
  3. filtrationthe solid product was collected by vacuum filtration

Sources & evidence

ORD record
ord-e28273258dbd4721b1f4011b89d2b9c7
Source dataset
uspto-grants-2007_10
Patent number
US07285556B2

Reaction notes

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