Lithium borohydride → HCID 58980888, compound

HRID 1181366Notes

Reaction equation

HRID 1181366 reaction equation
[F:1][C@@H:2]1[CH2:6][N:5]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[C@H:4]([C:14](OC)=[O:15])[CH2:3]1.[Li+].[BH4-]>C1COCC1>[F:1][C@@H:2]1[CH2:6][N:5]([C:7]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:8])[C@H:4]([CH2:14][OH:15])[CH2:3]1

Participants

4

Reactant 2

HCID 4148881Lithium borohydrideHCID 109777731,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-

Product 1

HCID 58980888HCID 58980888, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a THF (20 mL) solution of 1-tert-butyl 2-methyl (2S,4S)-4-fluoro-1,2-pyrrolidinedicarboxylate (950 mg, 3.9 mmol) at 0° C., 5.8 mL 2M LiBH4 (11.6 mmol, 3 eq) was added slowly. The resulting mixture was left stirring overnight while allowing the temperature to warm up to room temperature.

Workup

  1. waitThe resulting mixture was left

Sources & evidence

ORD record
ord-d8c9b8b67ee840b0a60d53dcc3ca815d
Source dataset
uspto-grants-2007_10
Patent number
US07285557B2

Reaction notes

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