Cinnolin-5-amine → N-Cinnolin-5-yl-N'-[4-(trifluoromethyl)benzyl]urea

HRID 1181447Notes

Reaction equation

HRID 1181447 reaction equation
[N:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.[F:12][C:13]([F:25])([F:24])[C:14]1[CH:23]=[CH:22][C:17]([CH2:18][N:19]=[C:20]=[O:21])=[CH:16][CH:15]=1>>[N:1]1[C:10]2[C:5](=[C:6]([NH:11][C:20]([NH:19][CH2:18][C:17]3[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:25])[F:24])=[CH:23][CH:22]=3)=[O:21])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

3

Reactant 2

HCID 387103Cinnolin-5-amineHCID 223376994-(Trifluoromethyl)benzyl isocyanate

Product 1

HCID 69523120N-Cinnolin-5-yl-N'-[4-(trifluoromethyl)benzyl]urea

Procedure

Prepared from cinnolin-5-amine (Sci Pharm. 1982, 50, 246) and [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to the procedure of Description 61. m/z (ES+) 347 (M+H)+.

Sources & evidence

ORD record
ord-62b79cc006ba4d1387f8bc5b847e6732
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

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