4-(Trifluoromethyl)benzyl isocyanate → N-(8-Fluoro-3-methylisoquinolin-5-yl)-N'-[4-(trifluoromethyl)benzyl]urea

HRID 1181478Notes

Reaction equation

HRID 1181478 reaction equation
[F:1][C:2]1[C:11]2[CH:10]=[N:9][C:8]([CH3:12])=[CH:7][C:6]=2[C:5]([NH2:13])=[CH:4][CH:3]=1.[F:14][C:15]([F:27])([F:26])[C:16]1[CH:25]=[CH:24][C:19]([CH2:20][N:21]=[C:22]=[O:23])=[CH:18][CH:17]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:13][C:22]([NH:21][CH2:20][C:19]2[CH:18]=[CH:17][C:16]([C:15]([F:14])([F:27])[F:26])=[CH:25][CH:24]=2)=[O:23])=[C:6]2[C:11]=1[CH:10]=[N:9][C:8]([CH3:12])=[CH:7]2

Participants

3

Reactant 2

HCID 223376994-(Trifluoromethyl)benzyl isocyanateHCID 691593638-Fluoro-3-methylisoquinolin-5-amine

Product 1

HCID 69522967N-(8-Fluoro-3-methylisoquinolin-5-yl)-N'-[4-(trifluoromethyl)benzyl]urea

Procedure

Prepared from 8-fluoro-3-methylisoquinolin-5-amine (Description 76) and [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to Description 61. m/z (ES+) 378 (M+H)+.

Sources & evidence

ORD record
ord-8baa34b07c034615b6d1dbd4b0758929
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

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