4-(Trifluoromethyl)benzyl isocyanate → N-(6-Fluoroisoquinolin-5-yl)-N'-[4-(trifluoromethyl)benzyl]urea

HRID 1181485Notes

Reaction equation

HRID 1181485 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[CH:8]=[N:7][CH:6]=[CH:5][C:4]=2[C:3]=1[NH2:12].[F:13][C:14]([F:26])([F:25])[C:15]1[CH:24]=[CH:23][C:18]([CH2:19][N:20]=[C:21]=[O:22])=[CH:17][CH:16]=1>>[F:1][C:2]1[C:3]([NH:12][C:21]([NH:20][CH2:19][C:18]2[CH:17]=[CH:16][C:15]([C:14]([F:13])([F:26])[F:25])=[CH:24][CH:23]=2)=[O:22])=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 223376994-(Trifluoromethyl)benzyl isocyanateHCID 450907626-Fluoroisoquinolin-5-amine

Product 1

HCID 69522782N-(6-Fluoroisoquinolin-5-yl)-N'-[4-(trifluoromethyl)benzyl]urea

Procedure

Prepared from 6-fluoroisoquinolin-5-amine (Description 89) and [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to Description 61. m/z (ES+) 364 (M+H)+.

Sources & evidence

ORD record
ord-7177b8e7db814409a203e39027ae342d
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

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