4-(Trifluoromethyl)benzyl isocyanate → N-[7-(trifluoromethyl)isoquinolin-5-yl]-N'-[4-(trifluoromethyl)benzyl]urea

HRID 1181491Notes

Reaction equation

HRID 1181491 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([NH2:13])[C:6]2[CH:7]=[CH:8][N:9]=[CH:10][C:11]=2[CH:12]=1.[F:16][C:17]([F:29])([F:28])[C:18]1[CH:27]=[CH:26][C:21]([CH2:22][N:23]=[C:24]=[O:25])=[CH:20][CH:19]=1>>[F:15][C:2]([F:1])([F:14])[C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][N:9]=[CH:10]2)=[C:5]([NH:13][C:24]([NH:23][CH2:22][C:21]2[CH:20]=[CH:19][C:18]([C:17]([F:16])([F:29])[F:28])=[CH:27][CH:26]=2)=[O:25])[CH:4]=1

Participants

3

Reactant 2

HCID 223376994-(Trifluoromethyl)benzyl isocyanateHCID 695223917-(Trifluoromethyl)isoquinolin-5-amine

Product 1

HCID 86598046N-[7-(trifluoromethyl)isoquinolin-5-yl]-N'-[4-(trifluoromethyl)benzyl]urea

Procedure

Prepared from 7-(trifluoromethyl)isoquinolin-5-amine (Description 99) and [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to Description 61. m/z (ES+) 414 (M+H)+.

Sources & evidence

ORD record
ord-7ceba74fb2bc4069919de583aebe5cfc
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

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