反应详情

A solution of 4-(N-tert-butoxycarbonyl-N-isopropylamino)piperidine (118 g, 0.49 mol) in dichloroethane (600 mL) was stirred at room temperature for 1 hour, and then 4-methoxypyridine-3-carboxylate (63.5 g, 0.46 mol) was added. The resulting solution was stirred at room temperature for 2.5 hours and then cooled to 5° C. in an ice/water bath. Sodium triacetoxyborohydride (124 g, 0.58 mol) in dichloroethane (600 mL) was added and the reaction mixture was stirred at 5° C. for 15 minutes. The ice bath was then removed and reaction mixture was stirred for 4 hours at room temperature. Acetic acid (30 mL) was then added to the reaction mixture and the resulting mixture was stirred for 0.5 hours, and then concentrated to half its original volume. This solution was cooled in a dry ice/acetone bath and 10 N aqueous sodium hydroxide (350 mL) was added. This mixture was stirred for 0.5 hours and then the organic layer was separated and washed with 1 N aqueous sodium hydroxide (400 mL). The aqueous layer was then washed three times with dichloromethane (400 mL) and the combined organic layers were dried over sodium sulfate (40 g). The sodium sulfate was filtered off and washed with dichloromethane (100 mL) and the combined organic layers were concentrated in vacuo to give 177 g of the title intermediate as a yellow oil (>99% yield; 74% purity by GC).

1. temperaturecooled to 5° C. in an ice/water bath
2. stirringthe reaction mixture was stirred at 5° C. for 15 minutes
3. customThe ice bath was then removed
4. customreaction mixture
5. stirringwas stirred for 4 hours at room temperature
6. stirringthe resulting mixture was stirred for 0.5 hours
7. concentrationconcentrated to half its original volume
8. temperatureThis solution was cooled in a dry ice/acetone bath
9. addition10 N aqueous sodium hydroxide (350 mL) was added
10. stirringThis mixture was stirred for 0.5 hours
11. customthe organic layer was separated
12. washwashed with 1 N aqueous sodium hydroxide (400 mL)
13. washThe aqueous layer was then washed three times with dichloromethane (400 mL)
14. dry with materialthe combined organic layers were dried over sodium sulfate (40 g)
15. filtrationThe sodium sulfate was filtered off
16. washwashed with dichloromethane (100 mL)
17. concentrationthe combined organic layers were concentrated in vacuo