Sodium Hydroxide → HCID 58981192, compound

HRID 1181563Notes

Reaction equation

HRID 1181563 reaction equation
[C:1]1([N:7]([C:34]2[N:39]=[CH:38][CH:37]=[CH:36][N:35]=2)[CH2:8][CH:9]([NH:14][C:15]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[NH:22][C:21]([C:26]2[CH:31]=[CH:30][N:29]=[C:28]([NH:32][CH3:33])[N:27]=2)=[CH:20]3)=[O:16])[C:10]([O:12]C)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[CH3:33][NH:32][C:28]1[N:27]=[C:26]([C:21]2[NH:22][C:23]3[C:19]([CH:20]=2)=[CH:18][C:17]([C:15]([NH:14][CH:9]([CH2:8][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:34]2[N:39]=[CH:38][CH:37]=[CH:36][N:35]=2)[C:10]([OH:12])=[O:11])=[O:16])=[CH:25][CH:24]=3)[CH:31]=[CH:30][N:29]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58981205HCID 58981205, compound

Product 1

HCID 58981192HCID 58981192, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.0 g of the methyl ester 46 were dissolved in 400 ml of methanol. 40 ml of a 2N aqueous solution of NaOH were added and the whole was stirred at room temperature for 12 h. After the solvents had been evaporated, the residue was dissolved with water and the pH was adjusted to 5 using a saturated solution of NaH2PO4. The resulting precipitate was filtered off and washed with water. This resulted in 1.3 g (yield 93%) of the acid 48.

Workup

  1. customAfter the solvents had been evaporated
  2. dissolutionthe residue was dissolved with water
  3. filtrationThe resulting precipitate was filtered off
  4. washwashed with water

Sources & evidence

ORD record
ord-c62a40115c8c436fba85e492f1ba1e83
Source dataset
uspto-grants-2007_10
Patent number
US07285560B2

Reaction notes

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