Sodium Hydroxide → HCID 58981192, compound

Participants

Reaction Steps

4.0 g of the methyl ester 46 were dissolved in 400 ml of methanol. 40 ml of a 2N aqueous solution of NaOH were added and the whole was stirred at room temperature for 12 h. After the solvents had been evaporated, the residue was dissolved with water and the pH was adjusted to 5 using a saturated solution of NaH2PO4. The resulting precipitate was filtered off and washed with water. This resulted in 1.3 g (yield 93%) of the acid 48.

Provenance & Evidence