反应详情

A mixture of 5,6-diamino-1-ethyl-3,3-dimethyl-1,3-dihydro-indol-2-one (10 g, 46 mmol), 2-hydroxy-propionic acid (9.13 g, 91.2 mmol) in HCl (100 mL, 4N) was refluxed for 16 h. After cooling, neutralization with aqueous ammonia (25%) and stirring for 1.5 h the precipitate was filtered and dried in vacuo at 50° C. yielding 12.29 g (95%) of a grey solid.

1. temperaturewas refluxed for 16 h
2. filtrationwas filtered
3. customdried in vacuo at 50° C.