Hydrazine hydrate (1:1) → HCID 178462877, compound

HRID 1181582Notes

Reaction equation

HRID 1181582 reaction equation
O.[NH2:2][NH2:3].CS[C:6]([S:33][CH3:34])=[CH:7][C:8]([C:10]1[N:26](C2CCCCO2)[C:13]2=[CH:14][C:15]3[C:16]([CH3:25])([CH3:24])[C:17](=[O:23])[N:18]([CH2:21][CH3:22])[C:19]=3[CH:20]=[C:12]2[N:11]=1)=O>C(#N)C>[CH2:21]([N:18]1[C:19]2[CH:20]=[C:12]3[N:11]=[C:10]([C:8]4[CH:7]=[C:6]([S:33][CH3:34])[NH:3][N:2]=4)[NH:26][C:13]3=[CH:14][C:15]=2[C:16]([CH3:24])([CH3:25])[C:17]1=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11583444HCID 11583444, compound

Product 1

HCID 178462877HCID 178462877, compoundYield 81.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Hydrazine monohydrate (0.92 g, 1.8 mmol) was added to a suspension of 2-(3,3-bis-methylsulfanyl-acryloyl)-5-ethyl-7,7-dimethyl-1-(tetrahydro-pyran-2-yl)-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (0.68 g, 1.81 mmol) in acetonitrile (15 mL) and stirred for 24 h. After cooling to room temperature the precipitate was collected, washed with acetonitrile and ether to yield 0.5 g (81%) of a pale white powder.

Workup

  1. customwas collected
  2. washwashed with acetonitrile and ether

Sources & evidence

ORD record
ord-aa5c7225fed44371a72c17f0204ee84c
Source dataset
uspto-grants-2007_10
Patent number
US07285569B2

Reaction notes

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